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自愿运动对光循环压力诱导的代谢抵抗的影响
Hyo Youl Moon1,2, In Cheol Jeong3
1Department of Physical Education, Seoul National University, Seoul, Republic of Korea.
Physical activity and nutrition
|November 10, 2023
概括
定期炼可以帮助预防由昼夜节律扰乱引起的代谢功能障碍. 这项研究表明,运动调节了骨肌肉中的昼夜基因表达,对代谢干扰产生保护作用.
科学领域:
- 时间生物学 时间生物学
- 代谢的恒常状态 代谢的恒常状态
- 运动生理学 运动生理学
背景情况:
- 循环基因干扰对代谢平衡有负面影响.
- 众所周知,定期运动可以预防代谢功能障碍,并影响昼夜基因表达.
研究的目的:
- 为了研究运动对轻度压力诱导的昼夜节律扰乱的影响.
- 为了确定运动是否赋予对昼夜节律失调的代谢抵抗力.
主要方法:
- 建立了一个生理节律失调的小鼠模型 (14 L/10 D).
- 鼠标接受了静坐或自愿的轮子训练条件,有或没有轻微的压力.
- 生物节律调节者的基因表达被用RT-PCR分析在小鼠和培养的髓管中.
主要成果:
- 轻度压力减少了跑步距离,增加了老鼠的体重.
- 运动和轻度压力改变了下丘脑和四头四脑的昼夜基因表达.
- 周期昼夜调节器1mRNA水平在压力较大的静止小鼠的四头肌下降.
结论:
- 运动部分地减轻了由昼夜节律失调引起的代谢干扰.
- 运动会影响骨肌肉中的昼夜基因表达,有助于新陈代谢调节.
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