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催化剂可以对风湿性关节炎引起的心肌损伤产生保护作用,转化增长因子β1信号和代谢重编程

Wang Miao¹, Zhu Yan², Zhao Hui¹

¹the Geriatrics, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

|November 10, 2023

概括

催化剂通过减少炎症和改善心脏功能,有效地治疗大鼠的类风湿性关节炎 (RA). 这种疗法可以通过调节TGF-β1通路和改变新陈代谢来起作用.

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
代谢学代谢学代谢学
传统中国医药传统中国医药

背景情况:

类风湿性关节炎 (RA) 可以导致心肌损伤.
转化生长因子β1 (TGF-β1) /Smads信号通路与RA和心脏功能障碍有关.
需要新的治疗策略来解决与RA相关的心血管并发症.

研究的目的:

为了研究摩克西布斯对心肌损伤的影响和RA的老鼠模型中的代谢学.
探索TGF-β1/Smads信号通路在moxibustion治疗效果中的作用.

主要方法:

通过使用完整的弗洛恩德辅助剂 (CFA) 建立了鼠类RA模型.
鼠被用摩克西布施 (MOX),针 (APT) 或Tripterygium wilfordii多糖化物片 (TPT) 治疗.
分析了心肌损伤标志物 (cTnI),TGF-β1/Smads通路组件和心肌代谢学.

主要成果:

与模型组相比,催化剂,针和TPT显著降低了RA症状和心肌损伤.
摩克西布施疗对关节胀和心脏功能有了更明显的改善.
催化剂治疗下调了关键的TGF-β1通路分子 (TGF-β1,Smad2,Smad3,Smad4) 和上调了Smad7.
代谢分析确定了一组与氨基酸,葡萄糖和脂肪酸代谢相关的生物标志物.

结论:

在老鼠中,moxibustion有效地减轻了RA诱导的炎症和心肌功能障碍.
催化剂的治疗效益可能包括TGF-β1途径的失活和代谢重编程.

关键词:

关节炎,类风湿性关节炎代谢生物组的代谢生物组催情运动是一种催情运动.心肌损伤是指心肌损伤.信号传导的信号传导.这是一种SMAD蛋白质.转化增长因子β1的转化增长因子β1

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