由口腔腔细菌引起的脑:全国性,基于人口的队列研究
Jacob Bodilsen1,2, Theis Mariager1, Lærke Storgaard Duerlund1
1Department of Infectious Diseases, Aalborg University Hospital Aalborg, Aalborg, Denmark.
概括
由口腔细菌引起的脑经常影响健康个体. 破裂和免疫性损害会使结果恶化,但特定的抗生素选择不会影响预后,支持节省卡巴的方法.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 微生物学 微生物学
背景情况:
- 口腔细菌是导致脑的主要原因.
- 关于这些感染的临床表现和结果的数据有限.
研究的目的:
- 研究由口腔细菌引起的脑的临床特征和预后因素.
- 确定与受影响患者不良结果相关的风险因素.
主要方法:
- 在丹麦 (2007-2020年) 进行的一项全国性基于人口的研究中,包括患有口腔细菌造成脑的成年人.
- 修改Poisson回归被用于分析不利结果的预后因素 (格拉斯哥结果尺度1-4).
主要成果:
- 确定了287名患者;33%是女性,平均年龄为58岁. 免疫性损害 (33%) 和牙感染 (24%) 是关键的危险因素.
- 不良结果 (37%) 与神经外科手术前的抗生素,瘤破裂和免疫性损害有关.
- 牙感染与良好的预后有关.
结论:
- 由口腔细菌引起的脑可以发生在健康个体中,通常没有先前的牙问题.
- 瘤破裂和免疫性损害是导致不良结果的重要危险因素.
- 抗生素治疗方案的选择没有影响结果,支持碳烯节约策略.
相关概念视频
Oral Cavity
749
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
749
Bacterial Phylum Actinobacteria
19
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
19
Pneumonia I: Introduction
247
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
247
Acute Pharyngitis
738
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
738
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Biofilms
29
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
29


