在怀孕前和期间接种COVID-19疫苗后流产的风险
Maud de Feijter1, Marleen M H J van Gelder2, Lieke C M Vissers1
1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands.
Pharmacoepidemiology and drug safety
|November 10, 2023
概括
在怀孕期间接种COVID-19疫苗并没有增加流产风险. 怀孕前接种疫苗与更低的流产风险有关,支持孕妇接种疫苗的安全性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 孕妇面临的SARS-CoV-2感染的风险更高.
- 接种COVID-19疫苗对于预防怀孕期间的严重疾病至关重要.
- 观察数据对于确认怀孕期间COVID-19疫苗安全性至关重要.
研究的目的:
- 评估COVID-19疫苗接种与流产风险之间的关联.
- 在怀孕前和怀孕期间评估疫苗接种安全性.
- 为孕妇提供知情的疫苗接种决定提供证据.
主要方法:
- 一项对4640名孕妇的队列研究 (2021年2月至2022年8月).
- 通过网络问卷,自报COVID-19疫苗接种和流产的数据.
- 使用调整的危险比率,进行生存分析以估计流产风险 (妊娠6-20周).
主要成果:
- 在怀孕期间接种COVID-19疫苗时没有观察到流产风险增加 (aHR = 1.29).
- 在怀孕之前接种COVID-19疫苗显示流产风险降低 (aHR = 0.69).
- 69%的参与者在妊娠2-20周之间至少接种了一次COVID-19疫苗.
结论:
- 在怀孕期间接种COVID-19疫苗与流产风险增加无关.
- 这些发现有助于证据基础的安全性COVID-19疫苗接种在孕妇.
- 在怀孕之前接种疫苗可能与流产率的降低有关.
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