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摄影氧催化静态交叉合反应

Zhenghong Zhou¹, Jimin Yang², Bo Yang¹

¹Frontiers Science Center for Transformative Molecules (FSCTM), Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.

Angewandte Chemie (International ed. in English)

|November 10, 2023

概括

这项研究引入了一种新的催化化交叉合反应,使用racemic stannanes. 这种更绿色的方法在温和条件下有效地形成碳-碳键,推进可持续合成.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
可持续化学可持续化学

背景情况:

斯蒂尔交叉合反应是C-C键形成的基石,但在成本,效率和可持续性方面面临挑战.
现有的催化静止反应是昂贵的,而racemic stannanes的enantioconvergent合是不发达的.
催化系统提供了一个具有成本效益的替代方案,但在开发方面落后,特别是在立体选择性转换方面.

研究的目的:

开发一种具有成本效益和酶选择性的催化Stille交叉合反应.
为了使C ((sp3) -C ((sp3)),C ((sp3) -C ((sp2) 和C ((sp3) -C ((sp)) 键从赛米干中合成.
建立一个更绿色,更可持续的替代传统的Stille合方法.

主要方法:

使用了一种协同的光/催化系统.
作为合伙伴,采用了赛米式斯坦试剂.
在温和条件下进行的反应:环境温度,没有添加剂,没有基.

主要成果:

实现了第一个enantioconvergent尼克尔催化静止交叉合的racemic stannanes.
产生了良好的高收益率的C-C债券,具有出色的立体选择性.
证明了一种新型的单电子转移通路,该通路由光电还原催化促进.

结论:

介绍了一种开创性的,实用的,可扩展的,操作上简单的C-C键形成的方法.
提供了一种更绿色,更具成本效益的替代品,以催化Stille反应.
通过创新的催化剂,为静态反应建立了一个新的研究范式.

关键词:

形成C−C键的方法合方式合方式合方式合方式合方式催化剂催化剂光催化作用的光催化沉默的反应沉默的反应

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