发育障碍的风险在32到38周怀孕出生儿童:一个元分析
Katherine J Pettinger1, Clare Copper2, Elaine Boyle3
1University of York, York, United Kingdom.
Pediatrics
|November 10, 2023
概括
中度早产 (32-36周) 的孩子面临更高的发育障碍的风险. 即使是晚期的早产和早产也显示出与满期分娩相比的风险增加.
科学领域:
- 新生儿发育的新生儿发展
- 儿科神经学 儿科神经学
- 公共卫生 公共卫生
背景情况:
- 非常早产 (<32周) 是发育障碍的已知危险因素.
- 新出现的证据表明,怀孕32周至38周之间出生的婴儿存在潜在风险.
研究的目的:
- 评估中度早产 (32-36周),晚期早产 (37-38周) 和早产 (39-41周) 婴儿发育障碍的相对风险和患病率.
- 将这些风险与满期婴儿 (≥37周或39-41周) 的风险进行比较.
主要方法:
- 在Medline,Embase,Psychinfo和CINAHL数据库中进行系统的文献搜索.
- 包括76项报告早产婴儿 (32-38周) 发育障碍的研究.
- 随机效应的元分析被用来汇集由单个审稿人提取的数据,其中20%的样本验证.
主要成果:
- 与按时出生的婴儿相比,中度早产,晚期早产和早产的婴儿对大多数发育障碍的风险增加.
- 脑的相对风险在中度早产婴儿 (32-33周: 14.1; 34-36周: 3.52) 中显著较高,在早产婴儿 (37-38周: 1.44) 中也较高.
结论:
- 在中度早产的婴儿中,发育障碍的风险大大增加.
- 晚期早产和早产与较小,但显著的风险增加有关.
- 需要进一步的研究,以了解不同人群的长期影响.
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