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调节T细胞和白素-35,白素-10和转化生长因子β对扩散大B细胞淋巴瘤的影响

Hao Wu¹, Hui-Cong Sun², Gui-Fang Ouyang³

¹Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China.

World journal of clinical cases

|November 10, 2023

概括

调控性T细胞 (Tregs),IL-35和IL-10与扩散型大B细胞淋巴瘤 (DLBCL) 的发展有关. 较高的Treg比例和升高的IL-35/IL-10水平表明疾病存在或复发,有助于预后分析.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
血液学血液学血液学

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的B细胞非霍奇金淋巴瘤.
关于免疫反应在DLBCL病变发生中的作用的研究有限.
了解免疫标记可以改善DLBCL的诊断和治疗.

研究的目的:

研究T调节细胞 (Tregs) 的表达和临床意义.
在DLBCL患者中分析Interleukin-35 (IL-35),Interleukin-10 (IL-10) 和转化生长因子-β (TGF-β) 的血清水平.
为了将这些标记与疾病状态和预后相关联.

主要方法:

79名DLBCL患者和30名健康对照者的回顾性分析.
将患者分为初始,有效治疗和复发耐药的组.
测量周围血液中的CD4+和CD8+Tregs,IL-35,IL-10和TGF-β水平.

主要成果:

与对照组和得到有效治疗的组相比,在初发性和复发性耐药DLBCL组观察到增加的CD4+Tregs,IL-35和IL-10.
两组之间CD8+ Tregs或TGF-β水平没有显著差异.
在IL-35,IL-10和TGF-β度之间发现了正相关性.

结论:

Tregs,IL-35和IL-10可能与DLBCL发生和进展有关.
这些标记物可以作为分析DLBCL预后的有价值指标.
对免疫调节的进一步研究可能会提供新的治疗策略.

关键词:

扩散大的B细胞淋巴瘤.免疫反应的免疫反应.介质蛋白-10 介质蛋白-10 是一种介质蛋白-35 介质蛋白-35 调节T细胞是T调节细胞.转化增长因子-β的转化增长因子

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