基于人工智能的MRI脑体积测定,用于患有基本震和震主导的帕金森病的患者
Veronika Purrer1,2, Emily Pohl1, Julia M Lueckel3
1Department of Neurology, University Hospital Bonn, 53127 Bonn, Germany.
Brain communications
|November 10, 2023
概括
基本震和帕金森病有共同的大脑结构变化,特别是在基底-甲状腺-甲状腺皮质电路中. 基于人工智能的大脑体积测量揭示了不同的模式,有助于区分这些震障碍.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 人工智能在医学中的应用
背景情况:
- 基本震 (ET) 和震主导的帕金森病 (TDPD) 呈现重叠的症状,导致诊断挑战.
- 之前对这些疾病的神经成像研究产生了有争议的结果,通常无法区分子类型.
研究的目的:
- 通过使用先进的神经成像来调查不同类型的震中不同结构性大脑特征.
- 为了比较ET和TDPD患者和健康对照者之间的大脑体积图案.
主要方法:
- 分析了61名ET和29名TDPD患者的结构性MRI扫描,使用基于人工智能的自动化大脑体积计.
- 卷度分析比较了皮层和皮下区域,包括基底,乳头和中脑.
- 回归分析评估了疾病相关因素对体积测量的贡献.
主要成果:
- 与对照人群相比,ET和TDPD患者在叶,海马体,骨,骨和中大脑中表现出结构性偏差.
- ET患者表现出尾状核和thalamus中的体积减少.
- 显而易见的模式出现了,在没有休息震的ET中出现了乳头缩,在TDPD和没有休息震的ET中出现了中脑/脑膜缩.
结论:
- ET和TDPD在基底 - - 甲状腺皮层电路中共享神经退行性结构变化.
- 基于人工智能的体积测量提供了一种快速,独立于评分者的方法,用于分析神经系统疾病中的大脑体积.
- 特定的区域性缩可能有助于区分ET亚型,并可能区分ET与TDPD.
相关概念视频
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).


