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来自Ganoderma resinaceum和Serpula similis (Agaricomycetes) 的类的表征和生物学研究

Tejal N Rikame¹, Preeti S Ranawade², Smriti P K Mittal²

¹Department of Chemistry, Ahmednagar College, Ahmednagar 414001, MH, India.

International journal of medicinal mushrooms

|November 10, 2023

概括

这项研究探讨了Ganoderma resinaceum和Serpula similis提取物的抗氧化和抗癌特性. 这两种提取物都显示出对癌细胞的显著细胞毒性和良好的抗氧化活性,表明潜在的制药应用.

科学领域:

菌类学菌类学是指菌类学.
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

甘树脂 (Ganoderma resinaceum) 和塞尔普拉 (Serpula similis) 的生物活动在很大程度上是未知的.
是一种丰富的生物活性化合物来源,具有治疗潜力.

研究的目的:

研究G. resinaceum和S. similis提取物的抗氧化,细胞毒性和细胞迁移效应.
确定负责这些生物活性的植物化学成分.

主要方法:

细胞毒性和细胞迁移检测是在人类癌细胞系 (HCT 116,肺癌) 上进行的.
使用DPPH和FRAP试验评估了抗氧化活性.
用LC-MS/MS进行了植物化学分析.

主要成果:

G. resinaceum和S. similis的提取物都对HCT 116细胞表现出显著的度依赖的细胞毒性.
提取物在肺癌细胞中显示出显著的抗迁移潜力.
两种提取物都观察到良好的自由基清除活性.
LC-MS/MS确定了各种代谢物,包括类,类和细胞毒性类.

结论:

G. resinaceum和S. similis的提取物具有显著的细胞毒性和抗氧化特性.
这些提取物可以成为制药和食品工业的宝贵自然资源.

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