一种新的环保和防水防晒剂:基于莱西的多层状脂质体
Antoine Bernasqué1,2, Chrystel Faure1, Hamid Rezvani2
1CBMN, Univ. Bordeaux, CNRS, Bordeaux INP, UMR5248, Pessac, France.
Journal of cosmetic dermatology
|November 10, 2023
概括
新的基于莱西丁的多层脂体 (MLL) 提供与商业防晒相比的环保防晒. 这些可生物降解的MLL提供了更好的皮肤粘附性,并改善了皮肤屏障功能,角层向MLL表现出卓越的性能.
科学领域:
- 皮肤病学和化品科学
- 材料科学是一种材料科学.
- 环境科学环境科学
背景情况:
- 皮肤癌率上升凸显了有效的紫外线保护的必要性.
- 传统的防晒会损害海洋生态系统,需要环保的替代品.
- 基于莱西丁的多叶质脂质体 (MLLs) 被探索为可持续的防晒成分.
研究的目的:
- 评估基于莱西的多层脂体 (MLLs) 作为一种可生物降解和环保的紫外线过器替代品.
- 研究MLL的大小和弹性的皮肤层向影响.
- 为了比较MLLs的性能与商业防晒在皮肤扩展剂上的性能.
主要方法:
- 测试了两个MLL组合物 (角质层的SC-MLL,表皮的Epi-MLL) 和一个商用SPF50+防晒.
- 皮肤扩展剂在制剂应用后被辐射.
- 组织学分析 (H&E,CPD免疫染色) 和体电阻 (TEER) 评估了紫外线保护和皮肤屏障质量.
- 还评估了皮肤的粘性.
主要成果:
- 在MLL测试中,阳光保护的有效性与SPF50+防晒相提并论.
- 与商业产品相比,MLLs表现出更好的皮肤粘附性.
- 在辐射后,MLL显著改善了皮肤屏障功能.
结论:
- 控制的基于莱西的MLL是有效的,环保的,耐水的太阳保护剂.
- 针对角质层的MLL (SC-MLL) 比针对表皮层的MLL (Epi-MLL) 提供更好的性能和成本效益.
- 肌肤屏障增强性质的MLLs可能有利于干燥或受损皮肤的个体.
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