睡眠障碍呼吸,缺氧和肺生理影响在心房
Catherine M Heinzinger1, Nicolas R Thompson2,3, Alex Milinovich2
1Sleep Disorders Center, Neurological Institute Cleveland Clinic Cleveland OH.
Journal of the American Heart Association
|November 10, 2023
概括
与睡眠相关的缺氧,一种与睡眠呼吸障碍相关的疾病,显著增加患心房动 (AF) 的风险. 即使考虑到肺功能,这种关联仍然存在,突出显示缺氧.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 肺部医学 肺部医学
背景情况:
- 与睡眠相关的缺氧和肺生理在心房 (AF) 的发展中的确切作用尚不清楚.
- 睡眠呼吸障碍是一种常见的疾病,可以影响心血管健康.
- 了解睡眠障碍和AF之间的相互作用对于患者管理至关重要.
研究的目的:
- 调查睡眠呼吸障碍,特别是睡眠相关的缺氧,与心房 (AF) 的发生率之间的联系.
- 为了确定肺生理障碍是否影响睡眠呼吸障碍和AF发展之间的关系.
主要方法:
- 从2000年1月2日至2015年12月30日期间进行的睡眠研究中对大量临床队列 (n=42,057) 的回顾性分析.
- 考克斯的比例危险模型被用来评估基于呼吸暂停-呼吸暂停指数,氧和度和潮尾二氧化碳的事件AF的风险.
- 对各种临床因素进行了调整,包括年龄,性别,种族,体重指数,心肺疾病,药物和肺功能测试 (呼吸计).
主要成果:
- 呼吸暂停-呼吸暂停指数的增加与AF风险的适度增加有关.
- 与睡眠相关的较高程度的缺氧 (较低的最低/平均氧和度,和时间增加<90%) 与发生AF风险的增加显著相关.
- 与睡眠相关的缺氧和发生的AF之间的关联即使在调整为肺功能指标后也仍然显著.
结论:
- 与睡眠相关的缺氧是心房动 (AF) 发展的重要独立风险因素.
- 这些发现表明缺氧在AF病变发生过程中发挥了直接作用,独立于肺生理功能障碍.
- 这些结果强调了在AF预防和管理策略中解决与睡眠相关的呼吸障碍的重要性.
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