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使用人性化小鼠识别有效的CCR2抑制剂用于癌症治疗

Shigeaki Sugiyama¹, Kanae Yumimoto¹, Shun Fujinuma¹

¹Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.

Journal of biochemistry

|November 10, 2023

概括

MK0812是最有效的C-C化学因子受体2型 (CCR2) 抑制剂,在人性化小鼠模型中显著减少乳腺癌肺转移. 这项研究强调MK0812是CCR2相关疾病的有前途的治疗候选者.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

2型C-C化学因子受体 (CCR2) 在炎症性疾病和癌症转移中发挥作用.
有许多CCR2抑制剂,但它们的临床疗效尚不清楚.
识别强效的CCR2抗剂对于治疗的发展至关重要.

研究的目的:

为了比较10种人类CCR2抗剂的疗效.
在临床前癌症转移模型中评估最强的抗体MK0812的治疗潜力.

主要方法:

流量测试用于选人类单细胞白血病细胞中的10种CCR2抗体.
为了评估MK0812在乳腺癌肺转移模型中的有效性,生成了人类CCR2B敲门鼠标模型.

主要成果:

在实验室中,MK0812在抑制人类CCR2方面表现出最高的功效.
在人性化小鼠中,MK0812的口服剂量降低了单细胞骨髓衍生的抑制细胞和肺转移率.
这些发现支持MK0812作为主要的CCR2抑制剂候选者.

结论:

在那些被测试的人中,MK0812是最有前途的CCR2抑制剂.
在体外查和人性化小鼠模型的结合提供了一个强大的方法来识别有效的CCR2抑制剂.
对于治疗CCR2介导的炎症性疾病和癌症转移,MK0812需要进一步研究.

关键词:

在C-C化学因子受体2型 (CCR2) 中.癌症转移的转移.这是一只模拟老鼠.淘汰赛小鼠淘汰赛小鼠单细胞骨髓衍生抑制细胞 (M-MDSCs) 是一种

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