Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

57
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
57
Typical Model Studies01:30

Typical Model Studies

363
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
363
Modeling and Similitude01:12

Modeling and Similitude

270
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
270

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A secondary upstream invasion of round goby in the Great Lakes Basin over fourteen years following a dam removal.

Journal of environmental management·2026
Same author

Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding.

PLoS computational biology·2026
Same author

Multimodal data integration to determine viral and innate immune kinetics in human airway epithelium.

PLoS computational biology·2026
Same author

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses.

Nature communications·2026
Same author

Comparison of glucose concentrations in simultaneously collected plasma and serum samples from outpatients in a routine laboratory setting.

PloS one·2026
Same author

PEtab-GUI: a graphical user interface to create, edit, and inspect PEtab parameter estimation problems.

Bioinformatics (Oxford, England)·2026

相关实验视频

Updated: Jul 11, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

3.5K

FitMultiCell:模拟和参数化多规模和多细胞过程的计算模型.

Emad Alamoudi1, Yannik Schälte1,2,3, Robert Müller4

  • 1Life and Medical Sciences Institute, University of Bonn, Bonn 53113, Germany.

Bioinformatics (Oxford, England)
|November 10, 2023
PubMed
概括
此摘要是机器生成的。

我们开发了FitMultiCell,这是一个开源管道,用于建模,模拟和参数化复杂的多尺度生物模型. 该工具解决了计算挑战,使系统生物学应用中多细胞过程的有效分析成为可能.

更多相关视频

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

1.8K
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

6.9K

相关实验视频

Last Updated: Jul 11, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

3.5K
Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

1.8K
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

6.9K

科学领域:

  • 系统生物学 系统生物学
  • 计算生物学 计算生物学
  • 生物物理学的生物物理.

背景情况:

  • 生物组织表现出复杂的动态,需要多尺度模型进行分析.
  • 对这些模型的参数推理是计算密集的,阻碍了定量理解和预测.
  • 像近似贝叶斯计算 (ABC) 这样的现有方法在复杂的模拟中面临可扩展性问题.

研究的目的:

  • 介绍FitMultiCell,这是一个开源管道,用于高效建模,模拟和参数化多尺度模型.
  • 为分析多细胞过程提供一个用户友好和可扩展的解决方案.
  • 促进系统生物学中的定量理解和假设测试.

主要方法:

  • 将Morpheus建模和模拟工具与pyABC统计推理工具集成.
  • 开发一个模块化管道,以实现无工作流的执行.
  • 实施高性能基础设施来处理计算要求高的问题.
  • 引入一种新的标准来制定参数推理问题,以确保可重现性.

主要成果:

  • 展示了FitMultiCell管道的计算效率和用户友好性.
  • 展示了管道在各种生物问题上的广泛应用.
  • 验证了管道处理整个工作流程的能力,从建模到参数化.
  • 通过标准化的问题制定,确保可复制性和可重复使用性.

结论:

  • 在多细胞系统中,FitMultiCell为多规模建模和参数化提供了可扩展和高效的解决方案.
  • 管道显著受益于基于图像的系统生物学研究.
  • FitMultiCell增强了对复杂生物过程进行定量分析,预测和理解的能力.