氨酸 - ангиотензин 系统的各种生物功能
Adithi Rao1,2, Shabir A Bhat1, Tomohiro Shibata1
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Medicinal research reviews
|November 10, 2023
概括
胺-血管素系统 (RAS) 不仅是一个循环的激素系统,而且在组织内局部发挥作用. 了解组织特异性RAS对于生理学和开发新疗法至关重要.
科学领域:
- 身体生理学 身体生理学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统上,氨酸-血管素系统 (RAS) 被认为是一种循环内分泌系统,可以调节血压.
- 新兴证据揭示了RAS成分在各种组织中的存在和功能,包括脏,大脑和免疫细胞.
- 这些发现表明存在独立的局部组织RAS.
研究的目的:
- 提供局部组织RAS的最新概述.
- 探索组织特异性RAS的组件,功能和医疗影响.
- 突出了解组织RAS对人类生理学和药物开发的重要性.
主要方法:
- 对组织特异性RAS研究的文献综述.
- 对非循环站点中的RAS组件的研究分析.
- 综合有关局部RAS的生理作用和临床相关性的信息.
主要成果:
- 拉斯成分在除了内分泌作用之外的各种组织中都存在.
- 局部组织RAS在特定器官中表现出独立的功能.
- 了解组织RAS对于解释药物效应和开发向治疗至关重要.
结论:
- 组织特异性RAS代表了我们对这个系统的理解的重大扩展.
- 对当地RAS的进一步研究对于推进人类生理学和医学至关重要.
- 向组织RAS可能为各种疾病提供新的治疗策略.
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