2023年丸癌:目前的状况和最近的进展
Deaglan J McHugh1,2, Jack P Gleeson3,4, Darren R Feldman1,2
1Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
CA: a cancer journal for clinicians
|November 10, 2023
概括
丸生殖细胞瘤 (GCT) 在年轻男性中很常见,治愈率显著提高. 然而,一些患者患上复发性或耐药性疾病,需要审查当前的治疗方法和进展.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 丸生殖细胞瘤 (GCT) 是青少年和年轻成年男性中最常见的固体恶性瘤.
- 在过去50年中,GCT管理的重大进展导致治愈率的提高,特别是在晚期疾病中.
研究的目的:
- 审查目前基于证据的额外内GCT治疗方法.
- 讨论与GCT治疗相关的急性和慢性毒性.
- 突出GCT管理中的当代进步和未来方向.
主要方法:
- 对额外内GCT的基于证据的治疗方法的文献综述.
- 对高级和耐火GCT的治愈率和结果的数据分析.
- 综合有关治疗相关毒性和新兴疗法的信息.
主要成果:
- 晚期GCT的治愈率已经从20世纪70年代的25%上升到近80%.
- 一部分患者 (20%) 经历了复发或耐药性疾病,死亡率很高.
- 目前的治疗重点是基于证据的策略,用于脑外GCT,管理毒性,并纳入新的进步.
结论:
- 虽然GCT结果有所改善,但对于复发或耐药性疾病患者来说,仍然存在挑战.
- 对当前的治疗方法,毒性和正在进行的研究有全面的了解,对于优化患者护理至关重要.
- 该领域的持续进展为GCT患者的生存率和生活质量进一步改善提供了希望.
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