来自iso-GGPP III的Diterpenoids的酶合成:一种具有转移双键的Geranylgeranyl二酸盐类似物

Heng Li1, Jeroen S Dickschat1

  • 1Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.

概括

研究人员合成了一种经过修改的二烯前体,即异基二酸盐 (iso-GGPP),并使用细菌酶制造出具有独特结构的九种新型二烯. 这项工作通过酶基质工程扩大了已知的二烯骨的多样性.

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