尿道癌中介质干细胞及其细胞外囊泡:前列腺,膀和脏癌症
Mohamed J Saadh1, Hayaa M Alhuthali2, Oblitas Gonzales Aníbal3
1Faculty of Pharmacy, Middle East University, Amman, Jordan.
Cell biology international
|November 10, 2023
概括
介酶干细胞 (MSC) 在癌症中表现出双重作用,既能对抗瘤,又能促进瘤的发展. 本综述探讨了它们在泌尿癌治疗中的潜力和挑战,包括使用细胞外囊泡 (EV) 的无细胞方法.
科学领域:
- 在瘤学瘤学.
- 干细胞生物学 干细胞生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 介质细胞干细胞 (MSCs) 具有多能性和免疫调节功能.
- 多重瘤细胞具有抗瘤和亲瘤性质,导致癌症中的复杂作用.
- 多重瘤细胞的双重性质和多样化的种群使其在癌症治疗中的使用变得复杂.
研究的目的:
- 在泌尿癌治疗中审查MSC及其细胞外囊泡 (EV) 的当前知识.
- 讨论基于MSC治疗膀,前列腺和癌的潜力和局限性.
- 探索MSC作为抗癌剂和自杀基因的输送工具.
主要方法:
- 在尿道癌症中对MSCs和EVs的研究的文献综述.
- 对MSC的抗瘤源和原瘤源机制的分析.
- 基于细胞和无细胞 (EVs) 的治疗策略的评估.
主要成果:
- MSCs在抗击癌症方面表现出潜力,但也促进瘤生长.
- 关于MSCs在泌尿癌 (膀,前列腺,脏) 中的特定作用的数据有限且相互矛盾.
- 来自MSCs的细胞外囊泡 (EVs) 正在成为有前途的无细胞治疗剂.
结论:
- MSCs为泌尿癌治疗提供了潜力,特别是作为药物/基因输送工具.
- 需要进一步的研究来澄清MSC的双重作用,并优化其治疗应用.
- 由MSC衍生的EVs代表了无细胞泌尿癌治疗的有希望的途径.
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