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Updated: Jul 11, 2025

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
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PKM2和PKM2:IP3R中断对细胞内Ca2+处理和细胞功能的复杂影响

Fernanda O Lemos1, Ian de Ridder1, Martin D Bootman2

  • 1Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, KU Leuven, Herestraat 49, Campus Gasthuisberg O&NI-B802, 3000 Leuven, Belgium.

Cells
|November 10, 2023
PubMed
概括

酸激酶M2 (PKM2) 调节细胞质和线粒体中的 (Ca2+) 处理. 干扰PKM2:氨基 1,4,5-三酸盐受体 (IP3R) 相互作用会触发细胞死亡,这取决于IP3R活动.

关键词:
在ER-线粒体的接触点.在IP3受体IP3受体.灭症 (apoptosis) 是一种死亡的过程.细胞内Ca2+信号传递.酸盐激酶M2的 pyruvate 激酶 M2 的 pyruvate 激酶 M2 的 pyruvate 激酶

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