聚离子复合聚合物的形成,由阴离子块共聚合物和阳离子多糖体形成
Kazushi Ogata1, Mineo Hashizume2, Rintaro Takahashi3
1Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
Langmuir : the ACS journal of surfaces and colloids
|November 10, 2023
概括
合成的多离子复合体 (PIC) 囊泡和小胞从生物相容的多二甲基氧乙基醇和阴离子多三甲基胺) 阻断共聚合物. 这些PIC表现出可调节的结构和特性,显示出药物输送应用的潜力.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 合成了组合生物相容的聚二甲基氧乙烯 (PMPC) 和阴离子聚三乙烯 (PMAPTAC) 的区块共聚物.
- 这些共聚合物被设计为形成聚离子复合物 (PIC) 聚合物与水溶液中的阳离子宏丁硫酸盐C (CS).
研究的目的:
- 研究由PMPC-PMAPTAC块共聚合物和CS.形成的PIC聚合物的形成和特征,特别是由PMPC-PMAPTAC块共聚合物和CS.形成的囊泡和小胞.
- 探索块共聚合物组成和环境条件 (pH,盐度) 对PIC结构和稳定性的影响.
- 评估这些PIC结构对离子分子封装的潜力.
主要方法:
- 使用可控基聚合来合成具有定义细分长度的PMPC-PMAPTAC块共聚合物.
- 通过在酸盐缓冲盐水中将阴离子CS与阴离子CS混合的阴离子块共聚合物来实现多离子复合.
- 动态光散射和泽塔电位测量被用来描述形成的PIC结构的水力动力半径,表面电荷和聚合数.
主要成果:
- 一种中和电荷的P20M101和CS混合物形成了带有PMPC外的PIC囊泡 (97.2nm水力动力半径).
- 一种P100M98和CS的混合物形成了PIC球形 (26.4纳米的水力动力半径),具有PIC核心和PMPC冠状.
- 由于CS碳酸盐质子化,PIC微粒核心密度在pH<4下降,在NaCl度≥0.6M时发生解离.
结论:
- PMPC-PMAPTAC块共聚合物有效地与CS形成PIC囊泡和小胞,展示基于共聚合物组成的可调自组装.
- 取决于pH值的结构变化和由盐引起的解离突显了这些PIC材料的响应性.
- 带正电荷的PIC微粒能够封装阳离子染料,这表明在有针对性的输送系统中有潜在的应用.
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