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ERK路径机制的新兴角色和机制感知机制

Flora Crozet¹, Romain Levayer²

¹Department of Developmental and Stem Cell Biology, Institut Pasteur, Université de Paris Cité, CNRS UMR 3738, 25 Rue du Dr. Roux, 75015, Paris, France.

Cellular and molecular life sciences : CMLS

|November 10, 2023

概括

机械力量调节细胞信号传递,特别是ERK通路,这对组织适应至关重要. 本综述强调了细胞变形和压力如何影响ERK信号,影响生理和病理过程.

科学领域:

细胞生物学细胞生物学
生物物理学的生物物理.
生理学生理学生理学

背景情况:

机械传导是细胞将机械刺激转化为生物化学信号的过程,对于组织的可塑性和适应性至关重要.
虽然像Hippo/YAP/TAZ和Piezo这样的途径已经得到了充分的研究,但细胞外信号调节激酶 (ERK) 途径在机械感知中的作用正在出现.
活细胞成像传感器的最新进展已经揭示了ERK通路对机械线索的快速和模块化反应.

研究的目的:

审查体内和体外证据,将细胞变形和机械应力与ERK信号调节联系起来.
探索机械力与ERK信号传递之间的相互作用背后的分子机制.
讨论ERK介导的机械感知在细胞协调和自我组织中的生理和病理影响.

主要方法:

对机械转导和ERK信号传递的体内和体外研究的文献综述.
分析使用活细胞传感器追踪机械应力下ERK路径动态的研究.
对不同系统的时间尺度和机械应力水平进行比较分析.

主要成果:

在各种生物系统中,细胞变形/机械应力和ERK通路激活之间建立了联系.
确定ERK作为一个快速和模块化的机械敏感通道.
突出了细胞参数对ERK信号传递对机械刺激的反应的影响.

结论:

该ERK通路是细胞对机械力反应的重要调解者.
了解机械-ERK相互作用对于理解组织适应,自我组织和细胞-细胞协调至关重要.
这一途径在生理过程和病理条件中具有潜在的相关性.

关键词:

癌症癌症癌症癌症欧洲农业基金会 (EGFR) 是一个.埃尔克·埃尔克是什么意思增长的增长增长的增长机械学机械学机械学机械转导是指机械转导的过程.形态发生形态发生形态发生这是一种自我组织.信号传输信号传输

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