儿童IgA病:COVID-19开始前后的情况
Esther Huimin Leow1, Siew Le Chong2, Celeste Jia Ying Yap2
1Paediatric Medicine, Nephrology Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore. Esther.Leow.H.M@singhealth.com.sg.
Pediatric nephrology (Berlin, Germany)
|November 10, 2023
概括
在COVID-19出现后,儿童IgA病 (IgAN) 的诊断率增加. 这表明COVID-19感染或接种疫苗可能会在儿科患者中引发Igan的发展.
科学领域:
- 儿科脏病学 儿科脏病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- IgA脏病 (IgAN) 是一种脏疾病.
- COVID-19的出现促使人们对其对儿科Igan诊断的潜在影响进行调查.
- 形成了一个假设,即COVID-19疫苗接种或感染可能会增加儿童Igan的临床表现.
研究的目的:
- 为了比较COVID-19大流行之前和之后诊断的儿科IgA病 (IgAN) 的临床过程.
- 调查COVID-19感染或接种疫苗是否与儿童Igan诊断的发病率增加有关.
主要方法:
- 使用了回顾性队列研究设计.
- 在2014-2020年 (期1) 和2021-2022年 (期2) 期间通过脏活检诊断出Igan的儿童被分析.
- 统计分析包括连续变量的威尔科克森等级总和测试和分类变量的奇平方或费舍尔精确测试.
主要成果:
- 该研究确定了19名患有Igan的儿童,其中10名在第1期和9名在第2期被诊断出Igan,这表明第2期的诊断率增加.
- 蛋白尿是脏活检的主要指示,在两个时期观察到的水平相似.
- 在两段时间之间没有发现临床过程的显著差异,没有患者需要替代疗法.
结论:
- 自COVID-19出现以来,儿童的IgA病 (IgAN) 诊断率较高.
- 这表明COVID-19在触发导致IgAN的免疫反应方面可能发挥作用.
- 需要进一步的研究来探索COVID-19和IgAN发展之间的联系,类似于其他粘膜感染.
相关概念视频
Acute Kidney Injury IV: Diagnostic Studies and Prevention
18
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
18
Acute Kidney Injury III: Clinical Manifestations
11
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
11
Nephrotic Syndrome I : Introduction
8
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
8
Acute Kidney Injury I: Introduction
12
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
12
Acute Kidney Injury II: Pathophysiology
9
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
9
Chronic Kidney Disease III: Interprofessional Care
13
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
13


