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肥胖和膜过率 肥胖和膜过率
Paula Schwartz1, Maria M Capotondo1, Miranda Quaintenne2
1Internal Medicine Division. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
International urology and nephrology
|November 10, 2023
概括
肥胖和减肥手术 (BS) 影响功能. 估计淋巴膜过率 (GFR) 需要仔细评估,因为影响肌水平的体重变化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢医学是一种代谢医学.
- 腹部外科 腹部外科
背景情况:
- 肥胖是慢性病 (CKD) 的重要风险因素,通过代谢综合征,糖尿病,高血压和炎症等机制.
- 肥胖相关的脏损伤包括交感神经系统的激活,氨酸-氨酸-阿尔多斯特系统的变化,机械压力,荷尔蒙失衡和炎症性细胞因子.
- 已建立的基于肌素的球过率 (GFR) 方程在肥胖个体和减肥手术 (BS) 后有局限性,原因是体重波动和肌血.
研究的目的:
- 分析肥胖和减肥手术对功能和GFR估计的影响.
- 讨论将肥胖与脏损伤联系在一起的机制.
- 评估GFR方程在体重变化的背景下可靠性的GFR方程的可靠性.
主要方法:
- 关于肥胖,CKD和减肥手术的当前文献的综述.
- 分析肥胖症中脏损伤的生理机制.
- 在肥胖患者和腹部外科后手术中评估GFR估计方法.
主要成果:
- 肥胖通过多种代谢和血液动力学途径导致CKD.
- 减肥手术可以改善或逆转关键的CKD风险因素,如糖尿病和高血压.
- 基于肌素的GFR测量在减肥手术后可能不可靠,原因是体重波动.
结论:
- 淋巴膜过率 (GFR) 受到肥胖和减肥手术的显著影响.
- 肥胖患者和腹部外科手术后患者的GFR值需要谨慎解释.
- 结合基于肌素和囊素的GFR方程,可以在这些患者中提供更准确的评估.
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