患者对肺癌拦截疗法的偏好
Ellen M Janssen1, Ian P Smith1,2, Xiaoying Liu3
1Global Epidemiology, Janssen Research and Development, Titusville, New Jersey.
JAMA network open
|November 10, 2023
概括
大多数高风险肺癌患者愿意考虑采用拦截疗法来降低风险. 减少肺癌风险是本次调查研究参与者最重要的因素.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 拦截疗法旨在预防未来的医疗事件,但其在肺癌高风险人群中的接受程度在很大程度上是未知的.
- 了解患者的偏好对于开发有效的肺癌拦截策略至关重要.
研究的目的:
- 探索高风险肺癌患者对潜在拦截疗法的偏好.
- 评估他们是否愿意接受治疗以减少肺癌风险.
主要方法:
- 一项离散选择实验在线调查,对50至80岁的美国成年人进行了调查,这些成年人有明显的吸烟史,有资格接受肺癌查.
- 参与者根据风险降低和副作用的严重程度 (注射部位反应,严重感染,死亡) 等属性评估假设的拦截治疗.
- 估计了属性级偏好权重,以计算重要性,最大可接受的风险和最小可接受的收益.
主要成果:
- 大多数受访者 (83.9%) 愿意考虑拦截治疗,优先考虑降低肺癌风险.
- 参与者指出,在增加非致命或致命严重感染风险和显著降低肺癌风险之间,可以接受的权衡.
- 不愿接受治疗的个人更有可能是老年人,目前的吸烟者,并且不太可能接受COVID-19或皮肤癌查.
结论:
- 大多数高风险肺癌患者表示愿意考虑采访疗法.
- 这些发现强调了对未来的肺癌拦截治疗进行彻底的益处风险评估的重要性.
- 患者的偏好应指导肺癌新型预防策略的开发和实施.
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