由斋月间歇性禁食引发的症状性异常性内高血压:一个病例报告
Ryan Nelson1, S L Silliman1, K Zarroli1
1Department of Neurology, University of Florida College of Medicine - Jacksonville, Jackonsville, FL, USA.
Nutritional neuroscience
|November 10, 2023
概括
斋月间歇性禁食可能会在易感个体中引发异常性内高血压 (IIH). 一个案例报告表明,禁食,GLP-1水平和内压力增加之间存在联系,为IIH病理生理学提供了新的见解.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 异常性内高血压 (IIH) 主要影响生育年龄的肥胖女性.
- IIH的确切病原体尚不清楚,有各种不同的建议病因.
- IIH的特点是内压升高,没有明确的潜在原因.
研究的目的:
- 报告一个因间歇性禁食引发的IIH独特病例.
- 探索潜在的病理生理机制,将禁食与IIH联系起来.
- 为了解IIH触发因素和机制做出贡献.
主要方法:
- 一个18岁的妇女的病例报告经历了IIH的新发症状.
- 临床检查,包括检查皮质瘤的底部影像.
- 腰部穿刺以测量开口压力.
- 在停止禁食和医疗治疗后评估症状的消失.
主要成果:
- 患者出现了头痛,双眼视和脉动性耳声.
- 双边 papilledema 和脑脊液 (CSF) 开口压力升高证实IIH.
- 症状在停止斋月间歇性禁食 (RIF) 后消失.
- 持久性耳声被成功用乙醇胺治疗.
结论:
- 这一案例表明,RIF可以导致症状IIH.
- 一个拟议的机制涉及禁食诱导的降低葡萄糖类-1 (GLP-1) 水平.
- 这种降低可能导致GLP-1受体激活的降低,CSF分泌的增加和内压力 (ICP) 的升高.
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