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Updated: Jul 11, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

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跨-BRCT链接器可能是BRCA1 BRCT域中最不容忍的区域

Fatemeh Yadegari1, Leila Farahmand2, Rezvan Esmaeili1

  • 1Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.

Journal of biomolecular structure & dynamics
|November 10, 2023
PubMed
概括

在BRCA1基因中识别不耐受区域有助于预测癌症风险. 该研究发现,BRCT之间的链接器具有高度不耐受性,突变会破坏蛋白质相互作用并增加对遗传性乳腺和卵巢癌的易感性.

关键词:
这就是BRCA1的原因.这就是VUS VUS VUS.互联BRCT连接器连接器不能容忍变化的变化.分子动力学 (MD) 模拟.转录激活 (TA) 测定试验

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