耳和/或听力损失的表显体标志
Carlos J Maldonado1, Jessica A White-Phillip1, Yuliang Liu2
1Department of Clinical Investigation, Womack Army Medical Center, Fort Bragg, NC 28310, USA.
Military medicine
|November 10, 2023
概括
服役超过16年的现役军人面临着 tinnitus 和/或听力损失 (THL) 的最高风险. 一种暴露性方法确定了这一群体中THL的关键风险因素.
科学领域:
- 军人卫生保健 军人卫生保健
- 曝光学 (Exposomics) 是一种表现学.
- 职业健康 职业健康 职业健康
背景情况:
- 耳和/或听力损失 (THL) 是军人社区中严重的健康问题.
- 了解风险因素对于制定有针对性的预防和管理策略至关重要.
- 暴露性方法提供了对环境和生活方式对健康的影响的全面观点.
研究的目的:
- 评估与美国陆军和海军航空社区 (AMAC) 现役成员的耳和/或听力损失 (THL) 相关的风险因素.
- 通过军事卫生系统中的暴露学框架来确定导致THL的因素.
- 确定个性化临床算法和THL预测模型的潜在目标.
主要方法:
- 使用医学评估和准备系统 (2015-2019) 的纵向数据进行了回顾性队列研究.
- 包括78,546名现役AMAC成员,包括220,044人年观察.
- 多变量混合效应物流回归分析,以评估THL与人口,生活方式和服务相关变量的关联.
主要成果:
- THL的发病率为每100人/年6.7,周期流行率为8.1%.
- THL与年龄,性别,体重指数,种族,部署,服役时间,婚姻状况和烟草使用有显著的关联 (P < .05).
- 超过16年的服役时间显示了THL (4.46,P < .001) 的最高赔率比率.
结论:
- 暴露学方法有效地识别了THL生物医学,生活方式,环境和随机风险因素的组合.
- 鉴定出的风险因素为THL的病因提供了洞察力,并可作为预测模型的基础.
- 对职业风险因素的进一步评估和生物标志物数据的纳入将提高理解和预测能力.
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