在空气道压力释放通风过程中受伤的肺部中持续 vs 内部招募:计算机建模视角
Andrea F Cruz1, Jacob Herrmann2, Harry Ramcharran3
1Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA.
Military medicine
|November 10, 2023
概括
气道压力释放通风 (APRV) 的设置会影响肺机械. 更高的吸入压力与更短的呼气时间可以优化气膜招募,并减少机械通风期间的肺损伤.
科学领域:
- 肺部医学 肺部医学
- 计算生物学 计算生物学
- 机械通风机械通风机械通风
背景情况:
- 循环膜招募和退出招募 (R/D) 在受伤的肺部造成异质的压力.
- 在急性肺损伤中,气膜R/D速率可能会发生变化,影响最佳通风参数.
研究的目的:
- 使用计算模型模拟气道压力释放通风 (APRV) 对acinar招募的影响.
- 为了调查不同的吸入压力水平和呼气持续时间如何影响APRV期间的肺机械.
主要方法:
- 开发了一个模拟呼吸机,呼吸回路,内管和带有受伤和过渡区的猪肺的计算模型.
- 通过膨胀依赖的表面张力模拟肺损伤;APRV参数 (吸入压力,呼气持续时间) 系统地变化.
主要成果:
- 较高的吸气压力 (40cmH2O与28cmH2O) 持续增加了持续的acinar招募和 intratidal R/D.
- 更长的呼气持续时间减少了持续的招募,但增加了入肠道R / D和减少了弹性.
结论:
- 计算建模突出了研发,招募和应变硬化在APRV期间对肺弹性造成的复杂相互作用.
- 较高的吸入压力增加了招募,但也增加了 intratidal R / D;建议使用较高的压力减轻更短的呼气时间.
相关概念视频
Pulmonary Ventilation: Inhalation
3.8K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Boyle's law becomes particularly pertinent when examining respiratory...
3.8K
Ventilatory Modes
180
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
180
Mechanical Ventilation II: Invasive Ventilation
156
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
156
Pressure Relationships in Thoracic Cavity
2.4K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
2.4K
Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
Mechanical Ventilation III: Noninvasive Ventilation
128
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
128


