压电纳米颗粒:Sono-Piezo动态疗法的核心P(VDF-TrFE) 的无序卷积区域
Zhiguang Chen1,2, Lizhi Yang1,2, Zhimin Yang2,3
1Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
ACS applied materials & interfaces
|November 10, 2023
概括
再结晶的压电纳米粒子 (rPGd NPs@RGD) 显示出用于脑质瘤的声压动态疗法 (SPDT) 和MRI成像的前景. 这些生物相容的纳米粒子通过在超声波下产生活性氧物种,有效地抑制瘤生长.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 聚乙烯化物-三乙烯 (PVF-TrFE) 具有出色的机械性能和生物相容性.
- 在SPDT中的P(VDF-TrFE) 的应用在很大程度上仍未被探索.
- 针对脑质瘤的向治疗需要具有成像能力的先进治疗剂.
研究的目的:
- 开发复合压电纳米粒子 (rPGd NPs@RGD) 用于双重MRI成像和针对脑质瘤的SPDT.
- 研究P(VDF-TrFE) 中再结晶对纳米粒子特性和SPDT疗效的影响.
- 评估开发的纳米粒子的生物相容性,稳定性和抗瘤活性.
主要方法:
- 再结晶的P(VDF-TrFE) 纳米颗粒 (rPGd NPs@RGD) 与RGD联的合成.
- 扫描电子显微镜 (SEM) 用于观察纳米粒子形态和在无序卷积区域 (DCR) 的再结晶.
- 在体外评估反应性氧物种 (ROS) 生成,细胞增殖,入侵和迁移的抑制.
- 在体内抗瘤疗效和MRI成像研究在U87瘤携带小鼠.
主要成果:
- 观察到P ((VDF-TrFE) 粒子在DCR中的再结晶,增强粒子极性.
- 与非再结晶的对应物相比,rPGd NPs@RGD 显示出更高的稳定性和生物相容性.
- 对rPGd NPs@RGD的超声刺激导致显著的ROS生成,有效地抑制质瘤细胞的增殖,入侵和迁移.
- 在体内研究证实了rPGd NPs@RGD在U87瘤携带小鼠中的卓越的MRI成像能力和显著的抗瘤活性.
结论:
- 微观的形态变化在P的DCR ((VDF-TrFE) 增强纳米粒子极性,提高SPDT的潜力.
- 开发的rPGd NPs@RGD是有效的sono-piezo动态疗法和脑质瘤的MRI成像.
- 这项研究突出了P ((VDF-TrFE) 材料在癌症治疗中用于先进的生物医学应用的潜力.
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