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与年龄相关的死亡率部分由差异化甲状腺癌中的TERT促进体突变状态介导
Jung Heo1, Sungjoo Lee2, Jun Park3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang-si, Gyeonggi-do, Korea.
PloS one
|November 10, 2023
概括
诊断时的年龄影响了差异化甲状腺癌 (DTC) 死亡率,TERT促进器突变调解了这一效应. 在分期中包括TERT突变可能会改善DTC预后预测.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 诊断时的年龄 (AAD) 和TERT促进子突变是已知的差异化甲状腺癌 (DTC) 的预后因素.
- TERT突变的患病率随着AAD的增加而增加,这表明存在潜在的相关性.
- 这项研究旨在探索AAD和TERT突变之间的相互作用以及TERT在AAD对DTC死亡率的影响中的调解作用.
研究的目的:
- 调查诊断时的年龄与差异化甲状腺癌 (DTC) 中的TERT促进子突变之间的相互作用.
- 确定TERT促进子突变是否调解了诊断时年龄对DTC患者死亡率的影响.
主要方法:
- 分析了393名DTC患者的甲状腺切除术后的情况.
- 使用多变量考克斯回归来检查AAD和TERT促进体突变之间的相互作用.
- 使用基于回归的因果调解模型来评估TERT突变的调解效应.
主要成果:
- 在所有DTC患者和野生型TERT组中,AAD的死亡率增加,但在突变TERT组中没有.
- 确定了AAD和TERT促进子突变之间的显著相互作用 (p = 0.005).
- 发现TERT促进子突变调解了ADD对DTC死亡率的影响的36%.
结论:
- 在DTC中,TERT促进子突变在诊断时的年龄和死亡率之间的关系中起着重要的调解作用.
- 将TERT促进子突变状态纳入分期系统可以增强DTC的个性化预后预测.
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