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儿童慢性病:血细胞计数指数作为炎症标志物的指数
Aislander Junio da Silva1, Ana Cristina Dos Santos Lopes1, Ana Paula Lucas Mota1
1Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte, MG, Brazil.
Jornal brasileiro de nefrologia
|November 10, 2023
概括
像淋巴细胞和单细胞比率 (LMR) 和全身炎症反应指数 (SIRI) 这样的血细胞计数指数显示出评估儿科慢性病 (CKD) 炎症的潜力. 这些标志物与CKD的原因和疾病阶段相关.
科学领域:
- 儿科脏病学 儿科脏病学
- 炎症生物标志物 炎症生物标志物
- 血液学 血液学 血液学
背景情况:
- 儿童的慢性病 (CKD) 往往源于脏和尿路的先天性异常 (CAKUT) 和质细胞病变.
- 炎症使儿科CKD的诊断和分期变得复杂,需要对新生物标志物的研究.
研究的目的:
- 评估血细胞计数衍生索引作为儿科CKD的潜在生物标志物.
- 确定这些指数与儿科CKD的病因和阶段之间的关联.
主要方法:
- 计算了六个血细胞计数指数:中性粒细胞-淋巴细胞比率 (NLR),衍生中性粒细胞-淋巴细胞比率 (dNLR),淋巴细胞-单细胞比率 (LMR),系统炎症反应指数 (SIRI),系统炎症总量指数 (AISI) 和系统免疫炎症指数 (SII).
- 在52名儿科慢性病患者 (按病因和阶段分类) 和33名健康对照人群之间的比较指数.
主要成果:
- 较低的淋巴细胞-单细胞比率 (LMR) 观察到儿科CKD患者与血球细胞病变 (阶段3-4) 和CAKUT (阶段3-4) 与健康对照组相比.
- 与健康对照组相比,在患有其他病因的儿科CKD患者 (第3至第4阶段) 中发现系统炎症反应指数 (SIRI) 的增加.
- 在其他评估指数中,没有发现群体之间的显著差异.
结论:
- 淋巴细胞-单细胞比 (LMR) 和全身炎症反应指数 (SIRI) 显示出在儿科CKD中炎症的潜在指标.
- 这些指数可能有助于评估CKD病因,特别是儿童的疾病病期.
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