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用双酸盐治疗骨质疏松症的长期后果
Bárbara Gehrke1,2,3, Maria Caroline Alves Coelho4,2,3, Catarina Brasil d'Alva5
1Programa de Pós-graduação em Fisiopatologia Clínica e Experimental (FISCLINEX), Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil, barbara_gehrke@yahoo.com.br.
Archives of endocrinology and metabolism
|November 10, 2023
概括
双酸盐有效增加骨矿物质密度,降低骨质疏松症骨折风险. 虽然罕见的副作用存在,但它们改善生活质量的好处通常超过这些风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 双酸盐 (BPs) 是骨质疏松症和脆弱性骨折的标准治疗方法.
- BPs对骨酸具有很高的亲和力,导致长时间的保留.
- 长期疗效和安全性数据对于临床决策至关重要.
研究的目的:
- 评估双酸盐治疗的长期益处和风险.
- 评估长期使用双酸盐对骨矿物质密度和骨折减少的影响.
- 权衡与长期治疗相关的罕见不良事件的优势.
主要方法:
- 来自主要临床试验的数据分析,包括骨折干预试验 长期延伸和健康结果以及使用佐勒龙酸减少发病率 每年一次的关键骨折试验.
- 对阿伦德罗纳酸 (长达10年) 和佐勒德罗纳酸 (长达6年) 长期使用的评估.
- 关于不良事件的文献综述,如非典型的股骨骨折和与药物相关的下巴骨硬化.
主要成果:
- 长期使用双酸盐可显著增加骨矿物质密度 (BMD).
- 长期治疗明显降低了脊椎骨折的风险.
- 罕见的不良事件,包括非典型的股骨骨折和下巴骨硬化,与高累积剂量和更长的治疗持续时间有关.
结论:
- 双酸盐在BMD增益和骨折风险降低方面提供了实质性的好处.
- 双酸盐的整体安全性和有效性已经得到了很好的证实.
- 双酸盐在改善生活质量和降低疾病死亡率方面的好处超过了罕见不良事件的风险.
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