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Updated: May 19, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

从怀孕23周到36周使用扩散核磁共振 (MRI) 描述胎儿大脑的微结构发育

Camilo Calixto^1,2, Fedel Machado-Rivas^2,3, Maria C Cortes-Albornoz^2,3

¹Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital, Boston, MA 02115, United States.

Cerebral cortex (New York, N.Y. : 1991)

|November 10, 2023

概括

这项研究使用扩散张力成像 (DTI) 追踪胎儿大脑发育,揭示了妊娠期间在关键大脑区域的分数异构性 (FA) 和平均扩散性 (MD) 中显著的微观结构变化.

科学领域:

神经成像是一种神经成像.
发育神经科学的发展神经科学.
生物医学工程生物医学工程

背景情况:

胎儿大脑发育涉及复杂的微观结构变化.
扩散张力成像 (DTI) 是评估白质微观结构的强大工具.
了解正常的胎儿大脑发育对于识别潜在异常至关重要.

研究的目的:

为了评估健康胎儿大脑的微结构变化,在第二和第三季度晚期使用运动校正的DTI.
描述不同胎儿大脑区域的分数异构 (FA) 和平均扩散 (MD) 的发育轨迹.
为了确定胎儿大脑发育中的潜在半球不对称性.

主要方法:

使用运动校正的扩散张力成像 (DTI) 来自44个胎儿 (23-36周妊娠年龄).
使用运动跟踪切片到体积注册框架重建的DTI.
使用胎儿DTI图谱对14个感兴趣区域 (ROI) 进行了细分,并使用混合效应模型分析了FA和MD的变化.

主要成果:

在大多数ROI中观察到FA和MD的显著妊娠年龄相关变化.
例外的是thalamus FA和corpus callosum MD,它们没有显示出任何显著的变化.
半球不对称性被检测到在周周白质 (pvWM),中间区域,亚板FA,以及状突出和pvWMMD.

结论:

这项研究为正常胎儿大脑的微观结构发育模式提供了宝贵的见解.
观察到的FA和MD的变化与细胞架构构的发展相关.
这些发现表明,在发育中的胎儿大脑中存在功能专业化的早期迹象.

关键词:

扩散张力成像扩散张力成像胎儿大脑胎儿大脑在活体中成像成像它的正常发育是正常的.

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