宿主反应变化及其与COVID-19淋巴细胞衰竭患者死亡率的关联
Erik H A Michels1, Brent Appelman1, Justin de Brabander1
1Center for Experimental and Molecular Medicine.
American journal of respiratory and critical care medicine
|November 10, 2023
概括
在COVID-19患者的淋巴缺血表明不同的宿主反应和增加的死亡率. 特定的免疫变化,如减少的CCL5,与更糟糕的结果有关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 淋巴衰竭是COVID-19中常见的发现,与较高的死亡率有关.
- 了解淋巴衰竭COVID-19中的宿主反应对于预测结果至关重要.
研究的目的:
- 为了研究淋巴缺血,宿主免疫反应模式和COVID-19患者的死亡率之间的关系.
- 识别与淋巴缺血相关的独特宿主反应表型及其对生存的影响.
主要方法:
- 在4个病理生理学领域测量了439名COVID-19患者的43个血生物标志物,按淋巴细胞计数分层.
- 利用集群分析在淋巴衰竭患者中识别宿主反应表型.
- 特定的淋巴细胞衍生蛋白度与死亡率相关联.
主要成果:
- 淋巴缺血与炎症,细胞因子/化学因子释放和内皮/凝血通路的显著改变有关.
- 淋巴细胞衍生的蛋白质水平降低,包括CCL5,IL-4,IL-13和IL-17A,与淋巴衰竭患者的死亡率增加相关.
- 确定了三种不同的宿主反应表型:低反应性 (9.5%的死亡率),高细胞动力 (5.1%的死亡率) 和炎症-损伤性 (26.4%的死亡率).
结论:
- 患有淋巴缺血的COVID-19患者代表了一个异质的群体,具有多样化的免疫系统调节障碍.
- 特定的宿主反应模式,特别是炎症-损伤性表型和降低的CCL5水平,显著导致淋巴缺血相关死亡率.
- 一个10个生物标志物模型有效地预测了外部队列中的这些表型.
相关概念视频
01:27Disorders of Leukocytes
963
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
963
01:26Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
01:27Cytotoxic T Cells-mediated Immune Response
928
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
928
01:40Cell-mediated Immune Responses
68.6K
Overview
68.6K
01:23Cells of the Adaptive Immune Response
999
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
999
01:29Immune Response Against Viral Pathogens
795
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
795