完全厚度的毛孔关闭与主题医疗治疗
Jessie Wang1, Sarah H Rodriguez1, Jason Xiao1
1Department of Ophthalmology and Visual Science, University of Chicago Medical Center, Chicago, Illinois.
Retina (Philadelphia, Pa.)
|November 10, 2023
概括
局部治疗实现了全厚黄斑孔 (FTMH) 的闭合率为36.7%. 较小的孔径和缺少玻璃瘤引力 (VMT) 改善了闭合几率,表明了潜在的非手术治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜外科手术 视网膜外科手术
- 医学疗法 医学疗法
背景情况:
- 全厚黄斑孔 (FTMH) 是视力障碍的一个重要原因.
- 手术干预,主要是帕斯普拉纳视切除术 (PPV),是FTMH的标准治疗方法.
- 对FTMH的非手术治疗选择有限,需要进一步的研究.
研究的目的:
- 评估使用局部治疗实现FTMH关闭的疗效和临床特征.
- 确定影响非手术治疗成功关闭FTMH的因素.
主要方法:
- 对49名在2017年至2022年期间被诊断患有FTMH的患者进行了回顾性病例系列.
- 患者接受了类固醇,碳酸酶抑制剂和非类固醇抗炎药 (NSAID) 眼滴的组合治疗.
- 数据分析的重点是关闭率,关闭时间,孔的大小,以及玻璃瘤引力 (VMT) 的存在.
主要成果:
- 局部治疗导致49只眼睛中的18只眼睛 (36.7%) 关闭FTMH.
- 较小的孔径与更高的闭合几率有显著的相关性 (P=0.001).
- VMT的存在与成功关闭相反相关 (OR6.1,P=0.029).
结论:
- 局部治疗为FTMH关闭提供了可行的非手术选择,成功率为36.7%.
- 在较小的孔和没有VMT的孔中,效率更高.
- 黄斑孔的缩小和中部骨厚度的减少预测了局部治疗的成功反应.
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