培养-交付 活益生菌 包裹 加快感染伤口愈合
Yihan Sun1,2, Manxuan Liu3, Xiaoduo Tang1,2,3
1State Key Laboratory of Supramolecular Structure and Material, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun 130012, China.
ACS applied materials & interfaces
|November 10, 2023
概括
这项研究介绍了一种新的活益生菌水凝敷料,提高了它们的活力,并防止伤口愈合期间的泄漏. 开发的敷料有效地对抗细菌感染,促进伤口愈合的速度更快.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 微生物学 微生物学
背景情况:
- 用于感染伤口愈合的益生菌疗法面临着益生菌活力低和殖民化的挑战.
- 需要有效的输送系统来维持益生菌的代谢活性,并防止在治疗期间的泄漏.
研究的目的:
- 设计和合成一种培养-交付活益生菌水凝敷料,用于感染的伤口愈合.
- 评估水凝保持益生菌活力的能力,控制泄漏,并施加抗菌作用.
主要方法:
- 合成了用诺伯 (GelNB) 和硫 (GelSH) 修改的等来合成水凝.
- 在 GelNB-GelSH 水凝 (GelNBSH-L) 中加入了带有 Lactobacillus reuteri (L. reuteri) 的酸微球 (AlgMP).
- 评估了水凝生物打印能力,聚合,益生菌活力,增殖,泄漏,以及对S. aureus和E. coli的抗菌疗效.
主要成果:
- 凝NBSH-L水凝表现出良好的生物打印能力和高效的聚合.
- 它成功地保持了活动,并促进了L. reuteri in situ的扩散,同时限制了泄漏.
- 对S. aureus和E. coli都取得了可持续的抗菌作用 (>90%).
结论:
- 开发的水凝保证了益生菌活力和抗菌特性,用于感染的伤口愈合.
- 它有效地抑制了细菌的生长,并加速了伤口修复周期.
- 这种方法有望改善益生菌生物治疗在伤口管理中的临床应用.
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