使用AMICA天线进行微波剥离建模:通过数值分析进行验证
A Cafarchio1, M Iasiello2, G P Vanoli1
1Dipartimento di Medicina e Scienze della Salute DIMES, Università degli Studi del Molise, Campobasso, Italy.
Computers in biology and medicine
|November 10, 2023
概括
一个新的预测模型准确地指导医生在肝脏瘤的微波热移除过程中,最大限度地减少附带损害. 这种经过验证的模型在预测脱落大小和形状时,在ex-vivo和in-vivo研究中都显示出高精度.
科学领域:
- 生物医学工程 生物医学工程
- 医学物理 医学物理
- 在瘤学瘤学.
背景情况:
- 穿皮微波热除使用电磁波进行介电加热,这是一个常见的瘤治疗方法.
- 在切除过程中最大限度地减少附带损害需要精确的程序指导.
研究的目的:
- 为了验证皮肤微波热废除程序的预测模型.
- 为医生提供指导方针,以避免瘤治疗期间的附带损害.
主要方法:
- 一个使用COMSOL多物理学的有限元模型,具有可变孔径和局部热不平衡 (LTNE) 方程.
- 采用了调参数方法,在体外模拟中改变血液流动速度和方向.
- 模型验证涉及回归分析,比较模拟结果与ex-vivo和in-vivo数据集.
主要成果:
- 该模型准确地预测了ex-vivo切除区域的大小和形状,高估值<10%.
- 对于体内数据,预测的消解体积低估了6%.
- 球状度指数预测 (0.75) 与体内数据 (0.62) 非常相匹配.
结论:
- 开发的预测模型显示了肝脏瘤微波切除的良好性能.
- 该模型准确地预测了ex-vivo和in-vivo数据的剥离尺寸和球状度指数.
- 进一步开发和验证是必要的,以提高in-vivo应用程序的准确性和可靠性.
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