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压力诱导的β细胞早期衰老可以防止1型糖尿病的发生

Hugo Lee1, Gulcan Semra Sahin1, Chien-Wen Chen2

  • 1Department of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53706, USA.

Cell metabolism
|November 10, 2023
PubMed
概括

在β细胞中删除特定的未折叠蛋白质响应 (UPR) 基因会触发早期衰老,增强M2巨细胞的招募,并解决炎症以保护1型糖尿病 (T1D). 这种衰老特征也在人类T1D患者中发现.

关键词:
压力ERER压力ERER压力在M2巨细胞中.在NOD小鼠中.通过UPR进行全日制检查.免疫监测监测是指免疫系统的监测.一些秘密一些秘密.衰老是一种老化.第1类糖尿病 1型糖尿病这种细胞是β细胞.

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