大脑功能分离,手性和认知 in situs inversus totalis:一个复制研究
Robin Gerrits1, Guy Vingerhoets1
1Department of Experimental Psychology, Ghent University, Ghent, Belgium.
Neuropsychologia
|November 10, 2023
概括
网站逆向总体 (SIT) 不一定意味着镜像式的大脑功能,尽管左撇子更常见. 在SIT患者中,内脏和大脑不对称性在很大程度上是独立的.
科学领域:
- 神经科学是一个神经科学.
- 人类遗传学 人类遗传学
- 发展生物学 发展生物学
背景情况:
- 网站逆向总体 (SIT) 是一种罕见的先天性疾病,内脏器官的左右完全反射.
- 以前的研究表明,SIT,不典型的大脑组织和认知缺陷之间存在联系.
研究的目的:
- 复制和扩展之前关于SIT患者大脑组织和认知功能的研究结果.
- 在一个更大的队列中调查内脏不对称性和大脑横向化之间的关系.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估23名SIT患者和23名对照者的半球对语言,手动实践,空间注意力和面部识别的主导地位.
- 神经心理学测试评估了认知能力.
- 来自前一个队列的数据被合并用于进一步分析.
主要成果:
- 认知功能在SIT个体中显示出预期的人口主导地位,尽管不如对照组那么明显.
- 非典型的大脑组织模式在SIT中更频繁,但没有统计学意义.
- 与一般人群 (10.6%) 相比,SIT组 (26%) 的左撇子明显更为普遍.
- 认知能力与器官网站或大脑组织无关.
结论:
- 内脏和神经不对称的决定因素在很大程度上是独立的.
- 完整的反向网站并不要求镜像的大脑功能架构.
- 特定的遗传机制有时可能会将内脏逆转与不典型的大脑横向性联系起来.
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