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亚丁酸基编辑器介导的拼接重塑激活了非正规的拼接地点

Yuanyuan Liu1, Qing Li2, Tong Yan3

  • 1School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou, Zhejiang, China; Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Hunan Normal University, Changsha, China.

The Journal of biological chemistry
|November 10, 2023
PubMed
概括

腺基编辑器 (ABE) 精确地改变了DNA. 这项研究表明,ABEs可以通过激活非正规拼接位来重塑基因拼接,从而为研究创造新的疾病模型.

关键词:
基编辑器的编辑器基因编辑 基因编辑非正规的接受者.拼接地点 拼接地点拼接接受器的拼接接受器

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