卵子捐赠者的最佳抗穆勒激素水平:国家数据库分析
Papri Sarkar1, Laura Zalles2, Wayne Caswell3
1Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Fertility and sterility
|November 10, 2023
概括
卵细胞捐赠者的高抗米勒尔激素 (AMH) 水平不会对接受者的妊娠结果产生负面影响. 与AMH水平较低的捐赠者相比,AMH≥5ng/mL的捐赠者表现出类似的持续怀孕率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵细胞捐赠 卵细胞捐赠
背景情况:
- 抗卵巢激素 (AMH) 是卵巢储备的一个关键指标.
- 在卵子捐赠者中,高AMH水平是常见的,但它们对受体结局的影响尚未完全理解.
- 了解这种关系对于优化捐赠者选择和接受者成功率至关重要.
研究的目的:
- 调查高AMH水平在卵细胞捐赠者和胚胎发育之间的关联.
- 评估高捐赠AMH对卵细胞接受者的妊娠结果的影响.
- 为基于AMH水平的卵细胞供体选择提供指导.
主要方法:
- 追溯性队列研究分析了从2013年至2021年的3,871个捐赠卵细胞-接受者周期.
- 卵细胞捐赠者被分为高AMH (≥5 ng/mL) 和参考 (<5 ng/mL) 两组.
- 综合估计方程模型用于分析每次胚胎移植 (ET) 和胚胎发育的持续妊娠率 (OPR).
主要成果:
- 来自高AMH捐赠者的周期显示,每批可用的胚胎数量显著增加 (RR 1.06).
- 在高AMH (45.4%) 和参考 (43.5%) 组 (RR 1.04) 之间没有观察到每ET的OPR显著差异.
- 胚胎euploidy率和每一个euploid ET的OPR在各组之间是可比的.
结论:
- 在卵细胞捐赠者中,高AMH水平 (≥5ng/mL) 与接受者持续怀孕率的降低无关.
- 预计具有高AMH水平的卵细胞捐赠者可以与具有较低AMH水平的卵细胞捐赠者产生类似的结果.
- 为接受者和医生提供关于使用具有高AMH水平的捐赠者的卵细胞的保证.
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