绝经后热的饮食干预:肠道微生物组的潜在作用. 一个探索性分析分析
Hana Kahleova1, Danielle N Holtz1, Noah Strom2
1Physicians Committee for Responsible Medicine, Washington, DC, USA.
Complementary therapies in medicine
|November 10, 2023
概括
一种含大豆的低脂肪素食饮食显著减少了绝经后妇女的发热. 这种饮食变化与肠道微生物组的特定变化有关,这表明饮食,肠道细菌和症状缓解之间存在潜在联系.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 妇女健康 妇女健康
背景情况:
- 血管运动症状,如热,在绝经后妇女中很常见.
- 正在探索饮食干预措施来管理这些症状.
- 肠道微生物组在调解这些影响中的作用尚未完全理解.
研究的目的:
- 调查肠道微生物组变化的作用,以应对饮食干预后绝经期血管运动症状的作用.
- 评估低脂肪,素食饮食与大豆对热频率和严重性的影响.
主要方法:
- 一项随机对照试验涉及84名绝经后妇女,她们经常出现热.
- 干预组每天接受低脂肪,素食饮食,每天大豆,持续12周.
- 肠道微生物组分析 (深度射门元基因组测序) 在基线和12周后对11名女性的子组进行.
主要成果:
- 饮食干预导致热总量 (95%),严重的热 (消失) 和中度至严重的热 (96%) 显著减少.
- 特定的肠道细菌,包括Porphyromonas和Clostridium asparagiforme,显示与减少热的严重性有关.
- 虽然一些细菌家族,属和物种的多样性不同,但在多次比较纠正后,这些变化在统计学上并不显著.
结论:
- 这项研究表明,饮食变化,肠道微生物组的修改和绝经后妇女血管运动症状的缓解之间存在潜在的关联.
- 进一步的大规模随机临床试验是有必要的,以证实这些探索性发现,并阐明底层机制.
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