瑞核酸还原酶作为药物重新利用的治疗标,作为杀虫剂
Marcelo Pasa Panesso1, Martin Cancela1, Renato Kulakowski Corá1
1Laboratôrio de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Laboratório de Biologia Molecular de Cestódeos, Centro de Biotecnologia, UFRGS, Porto Alegre, Brazil; Programa de Pós-Graduação Em Biologia Celular e Molecular, Centro de Biotecnologia, UFRGS, Porto Alegre, Brazil.
Experimental parasitology
|November 10, 2023
概括
开发新的防虫剂对于治疗内脏 cestodiases 是至关重要的. 这项研究确定了寄生虫核酸救援途径中的关键酶作为潜在的药物标,而核酸减少酶显示出药物重定位的希望.
科学领域:
- 寄生虫学的寄生虫学
- 药物发现 药物发现 药物发现
- 基因组学就是基因组学.
背景情况:
- 性骨病 (乙菌,囊性骨病) 是一种严重的动物传染病,治疗选择有限.
- 开发新型杀虫剂是紧急的公共卫生优先事项,特别是在欠发达地区.
研究的目的:
- 识别和评估细胞核酸救援途径中的酶,作为药物重新用途的潜在目标.
- 评估使用现有的药物治疗寄生虫虫感染的可行性.
主要方法:
- 在 silico 基因组调查中,确定了 28 种 purin 和 pyrimidine 救援途径酶在 * Echinococcus granulosus *.
- 评估酶的可用性和商业抑制剂的可用性.
- 对ortholog酶的家族遗传学分析和对E. granulosus*原生菌的氨酸尿素体内测试.
主要成果:
- 这种寄生虫利用基和核基获pyrimidines,并主要利用基获purin.
- 由于与人体正义学者的结构相似性,RNR被确定为一个有前途的药物标.
- 在体外用基尿素治疗抑制了*E. granulosus*原生的活力和DNA合成.
结论:
- 核酸救援通路中的酶代表了抗虫药物重新利用的可行目标.
- рибо核酸减少酶是开发针对内脏细胞病的新治疗方法的强有力的候选者.
- 抑制核酸合成为新型抗寄生虫疗法提供了一个有希望的策略.
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