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转移素受体向的非球状微气泡用于血脑屏障的声波透

Anshuman Dasgupta^1,2, Tao Sun^2,3, Elena Rama¹

¹Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, 52074, Aachen, Germany.

Advanced materials (Deerfield Beach, Fla.)

|November 10, 2023

概括

针对大脑的非球形微气泡 (MB).

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

微气泡 (MB) 由于表面张力而具有球形形状,限制了它们的应用.
不同类型的MB可以通过加热和拉伸聚合物MB.创建.
用向配体对表面进行修改,可以增强MB与特定组织的相互作用.

研究的目的:

为了研究非球形的,针对抗体的微气泡对增强血脑屏障 (BBB) 透的有效性.
为了比较非球形与球形MB的结合和声传导能力.
评估使用修改的MB向大脑提供向药物的潜力.

主要方法:

以聚合物为基础的球形MB被拉伸成杆状MB.
抗转移素被功能化为抗转移素受体 (TfR) 抗体.
超声波 (US) 和光学成像被用于评估MB结合和BBB透在体外和体内.

主要成果:

与球体对应物相比,非球体抗TfR-MB的结合效率对BBB内皮显著更高.
不同类型的MB产生了更强的空心信号.
在非球面的MB中观察到增强的BBB透和模型药物输送.

结论:

抗体修饰的非球形MB显示出在BBB的向药物输送方面具有卓越的性能.
不同类型的MB为超声波介导的治疗应用提供了独特的优势.
这种方法对推进大脑药物输送策略有前途.

关键词:

这就是PBCAA的PBCA.不同类型的异型性异型性血脑屏障是什么意思药物输送是药物输送的过程.这些微小气泡是微型气泡.超声波超声波是指超声波的使用.血管向的目标是血管.

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