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Updated: Jul 11, 2025

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在溶液中可视化GRP94的形状过渡

Shangwu Sun1, Rui Zhu1, Mengyao Zhu1

  • 1Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Life science alliance
|November 10, 2023
PubMed
概括

鼠标GRP94 (一种ER蛋白) 存在于扩展和紧的形式. ATP结合将GRP94转移到紧状态,而不是扩展状态,揭示了蛋白质折叠的独特动态.

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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
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