在肥胖人口中,甘油三糖指数与心血管死亡率之间的关联
Lin Du1, Xiaotian Xu2, Yong Wu1
1Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|November 10, 2023
概括
甘油三和葡萄糖 (TyG) 指数与肥胖个体的较高死亡率有关. 观察到所有原因死亡率的最低风险是TyG指数在8.78和9.64.6之间.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 心血管健康 心血管健康
- 肥胖问题研究研究
背景情况:
- 胰岛素抵抗是代谢障碍的一个关键因素.
- 甘油三和葡萄糖 (TyG) 指数作为胰岛素抵抗的替代标记.
- 之前的研究表明,TyG指数与死亡率增加之间存在联系.
研究的目的:
- 调查TyG指数与肥胖人口中所有原因死亡率之间的特定关联.
- 为了确定与该队列中死亡风险最低的TyG指数范围.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 中6731名肥胖参与者的数据.
- 使用禁食甘油三和葡萄糖水平计算了TyG指数.
- 在16.7年的随访期内使用Cox比例危险模型来评估死亡风险.
主要成果:
- 在TyG指数和全因死亡风险之间发现了非线性关联 (p=0.019).
- 所有原因死亡的最低风险发生在TyG指数范围内的8.789.64.
- 在最低四分位数中提升的TyG指数与增加的全因死亡率有关 (HR 1.32; p=0.030).
结论:
- TyG指数与肥胖个体的全因死亡风险有显著的关联.
- 一个TyG指数范围为8.789.64似乎与所有原因死亡率的最低风险有关.
- 这些发现强调了监测肥胖人口的TyG指数对于死亡风险评估的重要性.
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