血清肌胺/细胞胺C比率与高血压患者的死亡率之间的关系
Lihua Liao1, Shanshan Shi1, Bo Ding2
1Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China; The Third Clinical Medical College, Fujian Medical University, Fuzhou, 350000, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|November 10, 2023
概括
血清肌/细胞C比可以识别高血压患者的低肌肉质量 (LMM). 较低的比率表明LMM,并预测所有原因和心血管死亡率的风险更高.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 代谢疾病 代谢疾病
背景情况:
- 标志着肌肉质量和功能丧失的萨科佩尼亚与心血管疾病有关.
- 血清肌/细胞C (Cr/CysC) 比率是检测低肌肉质量 (LMM) 或肉症的简单指标.
- 高血压是心血管事件和死亡率的重要风险因素.
研究的目的:
- 确定Cr/CysC比率是否可以预测高血压患者的预后.
- 研究Cr/CysC比率与高血压患者的死亡结果之间的关联.
- 评估Cr/CysC比率作为这种人群中 Sarcopenia 的查工具的有用性.
主要方法:
- 一项涉及2509名高血压患者的队列研究,来自国家健康和营养调查 (1999-2002).
- 使用Kaplan-Meier估计和Cox回归分析来评估Cr/CysC比率与任何原因/心血管死亡率之间的关联.
- 计算了危险比率 (HR) 和95%置信区间 (CI) 来量化死亡风险.
主要成果:
- 在11.76年的中位数随访期间,较低的Cr/CysC比率与每0.1个增加的全因死亡率 (HR:0.81) 和心血管死亡率 (HR:0.80) 的风险降低有关.
- 患有LMM的高血压患者,通过较低的Cr/CysC比率来确定,与正常肌肉质量患者相比,所有原因死亡率 (HR: 1.57) 和心血管死亡率 (HR: 1.64) 的风险明显更高.
- 在高血压队列中,Cr/CysC比率与全因和心血管死亡率有显著的关联.
结论:
- 较低的Cr/CysC比率,表明肌肉质量较低,是高血压患者预后不佳的独立风险因素.
- 建议在高血压患者中对CR/CysC比率进行常规查.
- 对于高血压患者的低肌肉质量或肉症的早期干预可能会改善结果.
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