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Updated: Jul 11, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

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PRMT2通过防止核细胞退出和Tat的相分离进入超延长复合体来促进HIV-1潜伏

Jiaxing Jin1, Hui Bai1, Han Yan1

  • 1National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease of Ministry of Education, Department of Cell Biology, School of Basic Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, 300070, Tianjin, China.

Nature communications
|November 10, 2023
PubMed
概括

研究人员发现,PRMT2通过甲基化抑制HIV-1 Tat蛋白激活,从而促进病毒延迟. 这一发现为消除潜伏的艾滋病毒储存库提供了潜在的治疗目标.

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