支气管切除与肺癌查参与者的下肺功能有关
Anastasia K A L Kwee1, Bart Luijk2, Pim A de Jong3
1Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. A.k.a.l.kwee-2@umcutrecht.nl.
European radiology
|November 10, 2023
概括
支气管切除症在5.4%的肺癌查参与者中被发现,与增加的呼吸道症状有关. 在患有慢性阻塞性肺病 (COPD) 的个体中,它也与肺功能减弱和肺气的增加相关.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 支气管切除是胸部CT扫描中常见的一种偶然发现.
- 它在肺癌查人群中的临床意义尚不清楚.
- 了解这种关联对于准确的风险评估和患者管理至关重要.
研究的目的:
- 为了研究支气管和呼吸系统症状之间的关系.
- 评估与肺功能 (预测FEV1%,FEV1/FVC) 和肺的相关性.
- 为了区分这些关联在肺癌查参与者与或没有慢性阻塞性肺病 (COPD).
主要方法:
- 对来自NELSON肺癌查试验的3260名 (前) 吸烟者的分析.
- 经验丰富的胸部放射科医生对支气管切除症进行评分.
- 使用独立的t测试和多变量回归进行统计分析,以检查与肺功能,呼吸道症状和CT量化肺的关联.
主要成果:
- 支气管切除症在5.4%的参与者中被发现,COPD和非COPD组的患病率相似.
- 在COPD患者中,支气管切除与较低的FEV1%预测,较低的FEV1/FVC和增高的肺气显著相关.
- 支气管切除与COPD患者的咳,粘液过分和呼吸障碍,以及非COPD患者的咳,粘液过分和喘息相关.
结论:
- 支气管切除症发生在5.4%的肺癌查参与者中,与增加的呼吸道症状有关.
- 在患有COPD的参与者中,支气管切除与较差的肺功能和更多的肺气有关.
- 轻度支气管切除症的发现在肺癌查中通常具有有限的临床意义,除非同时存在轻度COPD.
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