在普通鱼 (Cyprinus carpio) 中,四博二甲基 (基乙烯) 的生物积累和生物转化
Jia Zhao1, Hongxia Zhao2, Zhihui Zhong1
1Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Environmental science and pollution research international
|November 10, 2023
概括
甲 (乙烯) (TBBPA-BAE) 在常见鱼中迅速积累,肝脏的度最高. 发生生物转化,产生14种代谢物,强调需要在风险评估中考虑这些产品.
科学领域:
- 环境毒理学环境毒理学
- 水生物质毒理学研究
- 制阻燃剂是一种制阻燃剂.
背景情况:
- 二甲基 (乙烯) (TBBPA-BAE) 是一种广泛使用的阻燃剂,已知对水生有毒性.
- 关于鱼类中TBBPA-BAE衍生物的生物度和生物转化存在有限的数据.
- 之前的研究集中在母化合物四博二甲 (TBBPA) 上.
研究的目的:
- 研究普通鱼 (Cyprinus carpio) 中的TBBPA-BAE的组织特异性吸收,排泄动力学和生物转化.
- 评估TBBPA-BAE及其代谢物在水生生态系统中的环境风险.
主要方法:
- 在28天的时间里,将常见鱼暴露在TBBPA-BAE的环境相关度 (20μg·L−1) 中.
- 随后的14天净化期用于研究排泄动力学.
- 在七种组织中分析TBBPA-BAE度,并确定肝脏中的代谢物.
主要成果:
- TBBPA-BAE在普通鱼组织中迅速积累.
- 肝脏在24日表现出最高的TBBPA-BAE度 (6.00μg·g−1 ww).
- 脏显示了最长的停留时间 (t1/2 = 18.7 天).
- 在肝脏中发现了14种TBBPA-BAE的I期和II期代谢物.
结论:
- 在普通鱼中,TBBPA-BAE经历了显著的生物转化.
- 确定了TBBPA-BAE的代谢物,需要考虑进行全面的生态风险评估.
- 需要进一步的研究来了解TBBPA-BAE代谢物的毒理学特征.
相关概念视频
Bioremediation
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
Drug Biotransformation: Overview
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
Drug Biotransformation: Overview
Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
Phase II Reactions: Miscellaneous Conjugation Reactions
Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
Lipid Catabolism
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...


