总和直接 bilirubin 的升高与急性复杂尾炎有关:沙特阿拉伯的一项单中心研究
Mohammed S Alfehaid1, Ayman M Babiker2, Abdullah Hamad Alkharraz3
1Department of Surgery, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
BMC surgery
|November 10, 2023
概括
总和直接胆红素水平升高可以帮助预测急性复杂尾炎. 这项在沙特阿拉伯的研究表明,胆红素是辅助诊断因素,而不是独立测试.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 手术紧急情况 手术紧急情况
- 生物化学 生化学
背景情况:
- 尾炎是一种常见的手术紧急情况.
- 在沙特阿拉伯,特别是卡西姆地区,没有先前的研究研究过胆红素作为预测因子.
- 这项研究通过检查胆红素在复杂尾炎中的作用来弥补这一缺口.
研究的目的:
- 确定总和直接胆红素水平是否可以预测急性复杂尾炎.
- 为了在诊断复杂尾炎时确定胆红素的切线值.
- 评估 bilirubin 在这个特定的沙特阿拉伯人口中的诊断效用.
主要方法:
- 在沙特阿拉伯Unaizah的沙特国王医院进行了回顾性观察研究.沙特阿拉伯Unaizah,沙特阿拉伯.
- 包括158名被诊断患有急性尾炎的患者.
- 数据收集包括人口统计,并发症和肝功能测试 (总和直接胆红素,AST,ALT),电解质和白细胞计数.
主要成果:
- 多变量分析显示,总和直接 bilirubin 的升高与复杂的尾炎显著相关 (分别为 aOR=3.79 和 aOR=4.74).
- 确定了最佳切线值:总胆红素≥15μmol/L (灵敏度57.6%,特异性73.6%) 和直接胆红素≥5μmol/L (灵敏度54.6%,特异性80%).
- 在研究的158名患者中,有20.9%的人患有复杂的尾炎.
结论:
- 在沙特阿拉伯的卡西姆地区,总和直接胆红素水平升高与急性复杂尾炎有关.
- 胆红素应该被认为是复杂尾炎的支持性诊断标记物.
- 单独的白素水平不足以独立诊断复杂的尾炎.
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